Author:
Edition: 1
Binding: Hardcover
ISBN: 3527330151
Edition: 1
Binding: Hardcover
ISBN: 3527330151
Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry)
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. br>As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section. Read medical textbooks online like Bioisosteres in Medicinal Chemistry here
Bioisosteres In Medicinal Chemistry By Brown, Nathan (edt)/ Mannhold, Raimun...
John Wiley Sons Inc 9783527330157 Bioisosteres in Medicinal Chemistry By Brown, Nathan (EDT)/ Mannhold, Raimund (EDT)/ Kubinyi, Hugo (EDT)/ Folkers, Gerd (EDT) Description *Author: Brown, Nathan (EDT) *Series Title: Methods and Principles in Medicinal Chemistry *Publication Date: 2012/10/23 *Number of Pages: 237 *Binding Type: Hardcover *Language: English *Depth: 0.50 *Width: 6.75 *Height: 9.25 SKU: UBM9783527330157 Payment We accept payment via PayPal, Mastercard, Visa, American Express, Disco
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologi
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologi
Publication Date: October 15, 2012 | ISBN-10: 3527330151 | ISBN-13: 9783527330157 / 9783527654321 | Edition: 1 Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,while the second part describes a number of molecular databases a
*Author: Brown, Nathan (EDT) *Series Title: Methods and Principles in Medicinal Chemistry *Publication Date: 2012/10/23 *Number of Pages: 237 *Binding Type: Hardcover *Language: English *Depth: 0.50 *Width: 6.75 *Height: 9.25
Bioisosteres in Medicinal Chemistry Online
br>As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development
The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal
